Active Ingredient (s) APO- Isosorbide Mononitrate. [13] Hence the sublingual route, which avoids the first-pass effect, is preferred to achieve the therapeutic levels rapidly. Isosorbide is a medication used to treat and prevent angina pectoris in patients with coronary heart disease. They differ from each other according to their applications and properties. Isosorbide mononitrate (Monoket) can cause headaches, dizziness, or lightheadedness. Oral use. Do not use extended-release isosorbide dinitrate preparations or any isosorbide mononitrate preparation to abort an acute anginal episode or for acute relief of angina or in the prophylactic management in situations likely to provoke angina attacks; onset is not sufficiently rapid. Importance of informing patients of other important precautionary information. What is the difference or advantage of using isosorbide dinitrate over isosorbide mononitrate? Sublingual or intrabuccal nitrates may be inadequately absorbed, with resultant decreased efficacy, in patients with dry oral mucous membranes (e.g., xerostomia). However, this may be hazardous in renal failure and congestive heart failure patients. Nitrates - Knowledge @ AMBOSS Describe the potential adverse effects patients may experience when using isosorbide. Severe hypotension, particularly in upright position, can occur even with low doses. Isosorbide mononitrate (ISMN) is the active metabolite of ISDN and is primarily used in the management of chronic stable angina. Imdur is a vasodilator and Ranexa is an anti-anginal medication. Plasma concentrations and urinary excretion of isosorbide dinitrate and its metabolites in the dog. Drinking alcohol can increase the effects of isosorbide mononitrate and dinitrate. There is no clear evidence that isosorbide mononitrate or dinitrate affects fertility in men or women. An interdosing interval sufficient to avoid tolerance to Dilatrate-SR extended-release capsules is not known, but it must exceed 18 hours.
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