Consequently, functional defects in patients with PVL are highly dependent on location of insult. Citation, DOI & article data. Pathologic changes consisted of infarction and demyelination of periventricular white matter, with associated necrotic foci in the basal ganglia in some cases. [5], Although no treatments have been approved for use in human PVL patients, a significant amount of research is occurring in developing treatments for protection of the nervous system. Therapeutic hypothermia for neonatal encephalopathy: a UK survey of opinion, practice and neuro-investigation at the end of 2007. Have certain findings on their MRIs of the brain, such as periventricular leukomalacia, which represents a little bit of volume loss in certain areas of the brain. Periventricular Leukomalacia | Boston Children's Hospital Guide To The Causes And Risk Factors Of Periventricular Leukomalacia In severe cases, post-mortem examinations revealed that 75% of premature babies who died shortly after birth had periventricular leukomalacia. Periventricular leukomalacia can lead to physical and mental development issues. The early signs of PVL include periventricular white matter necrosis followed by the subacute stage with possible intraparenchymal cyst formation and the late stages of parenchymal loss and enlargement of the ventricles. The periventricular area-the area around the spaces in the brain called ventricles-contains nerve fibers that carry messages from the brain to the body's muscles. Pathologic changes consisted of infarction and demyelination of periventricular white matter, with associated necrotic foci in the basal ganglia in some cases. Unauthorized use of these marks is strictly prohibited. The pathological findings in four patients with courses characterized by acute coma and respiratory insufficiency occurring in obscure circumstances are presented.
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